High Resolution Electron Microscopy at the National Cancer Institute

3D structure of trimeric HIV-1 spike

3D structure of trimeric HIV-1 spike. See article by Liu et al (2008).

Press Release: Structure of trimeric HIV-1
1. NCI News

Architecture of simian immunodeficiency virus determined using cryo-electron tomography

Architecture of simian immunodeficiency virus determined using cryo-electron tomography. See article by Sougrat et al (2007).

Press Releases: HIV Molecular Entry Claw
1. NIH News
2. NIH Research Matters

The long-term mission of our research program is to obtain an integrated, quantitative understanding of cells and viruses at molecular resolution. We take an interdisciplinary approach to this problem by combining novel technologies for 3D imaging with computational and cell biological tools.

Our research efforts are presently focused on three areas:
(i) determination of the dynamic architecture of the bacterial chemotaxis apparatus and quantitative understanding of steps in signal transduction, (ii) determination of the structure, and mechanisms underlying neutralization and cellular entry of HIV, and (iii) the development of novel technologies for 3D imaging of cells and tissues, with particular emphasis on methods for understanding and diagnosing structural signatures of cancer cells.

The technological infrastructure of the laboratory includes electron microscopes capable of operation at 120 kV and 300 kV (FEG instrument), as well as extensive facilities for high speed and parallel computing. The laboratory is located in a newly constructed research building on the NIH campus which houses groups whose interests range from computational biology, bioinformatics, X-ray and electron crystallography to cell biology, genetics and genome research.

If you are interested in applying for a position as a student or postdoctoral fellow, please send a CV, a brief statement of research interests, and the names of three references by electronic or regular mail to:

Sriram Subramaniam
Biophysics Section
Laboratory of Cell Biology
National Cancer Institute
Bethesda, MD 20892

E-mail: ss1@nih.gov
FAX: (301) 480-3834
TEL: (301) 594-2062

National Institutes of Health (NIH)
Bethesda, Maryland 20892

Department of Health and Human Services

National Cancer Institute \ Center for Cancer Research

Laboratory of Cell Biology